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What is the appropriate volume to re-irradiate in a recurrent GBM?
If a patient has increasing FLAIR and T1 enhancing activity, should both be included in the treatment volume? What factors to you consider in making your decision (such as PFS since prior CRT, KPS, etc)?
Answer from: Radiation Oncologist at Academic Institution
We need to recognize there is no standard dose fractionation regimen for re-irradiation in recurrent GBM. The volume and CTV/PTV margin are heavily depended on the dose/fraction you pick for your patients, and radiation techniques. The most commonly accepted regimen is probably 35 Gy in 10 fractions...
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