What is the practical application of alpha-synuclein seed amplification assay CSF testing for the diagnosis and management of Parkinson's disease?
In light of commercially available SYNTap CSF testing.
Answer from: at Academic Institution
The α-synuclein seed amplification assay (αSyn-SAA) sensitively identifies patients with Parkinson’s disease from cerebrospinal fluid (CSF) samples. A positive αSyn-SAA is proposed to "biologically define" Parkinson’s disease and anchor disease staging. A positive &alph...
Comments
at OhioHealth Dr. @Espay, have you found a reliable commercial e...
I use skin biopsies which have good reported sensitivity and specificity to diagnose PD/DLB and MSA (Gibbons et al., PMID 38506839), and anecdotally able to distinguish between PD/DLB and MSA (Gibbons et al., PMID 36657992).In my practice, I use skin biopsies when the differential includes tardive p...
Dr. @Espay, have you found a reliable commercial e...