What is the significance of PNI in oropharyngeal cancer?
Do you take this into consideration when recommending treatment?
Answer from: Radiation Oncologist at Academic Institution
Perineural invasion (PNI) is a risk factor for local recurrence for oropharyngeal cancers (Routman et al., PMID 28847412). I have infrequently seen gross named nerve invasion with OPX tumors, so it is usually an intermediate risk factor. When named nerve invasion does occur, it is generally hypoglos...