What is the your choice of treatment after progression or AE following pembrolizumab in metastatic melanoma?   

There is unfortunately limited prospective randomized data to guide us after progression due to anti-PD-1 therapy in metastatic melanoma. There is little benefit to re-challenging with the other anti-PD1 therapy (pembro or nivo after nivo or pembro etc) and dependent on AE would most likely not...