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Topics:
Internal Medicine • Rheumatology • Thrombosis • Hematology • General Rheumatology • Neurology • Neuromuscular • Neuro-immunology
What is your approach to DVT prophylaxis in patients who require IVIG but are at increased risk for thrombotic events?
E.g., a patient with newly diagnosed CIDP who is wheelchair-bound.
Answer from: at Academic Institution
I am unaware of any published data to guide the decision-making for this topic. Empirically, I recommend low-dose aspirin in patients >50 who have to get long-term IVIG especially if there are a lot of underlying risk factors for thrombosis like diabetes, immobility, etc. Again, this is not an ev...
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Answer from: at Community Practice
There's not much available literature on this, but the risk is probably related to peak dosing. I couldn’t find a report of thrombosis with SCIg, but the warning is there and the risk must be very low. So, I would use SCIg when I can. Otherwise, my approach is to spread the treatment out; lowe...