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Topics:
Gastrointestinal Cancers • Medical Oncology
What is your approach to systemic therapy in newly diagnosed colon cancer with synchronous solitary liver metastases?
Do you offer chemotherapy upfront in all patients or only if borderline resectable/unresectable? If you treat, what regimen do you use and how long before proceeding to surgery, given associations of steatosis with 5-FU/irinotecan and sinusoidal obstruction syndrome with oxaliplatin?
Answer from: Medical Oncologist at Community Practice
This is an important and challenging clinical question. In general, I favor a neoadjuvant chemotherapy treatment approach for a variety of reasons. For one, the EORTC trial provides us with supportive data that perioperative FOLFOX is associated with a modest improvement in outcome compared to sur...
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