What is your approach to treating premenopausal woman with OI with a new compression fracture?  

Young women with idiopathic premenopausal osteoporosis likely have low bone formation. I was not told her BMD but I will assume it is low. An antiresorptive does not make much sense because she is producing enough estrogen to keep her cycles going.  There has been some published data with th...

Osteogenesis imperfecta (OI) is a heterogeneous group of inherited disorders of bone formation that results in low bone mass, bone fragility, and an increased predisposition to fracture. Most OI is caused by pathogenic variants in genes that encode type 1 collagen with an autosomal dominant pattern ...