What is your preferred radiation sensitizing regimen for cisplatin-ineligible patients with locally advanced unresectable p16+ tonsil SCCa?  

If patients are not candidates for cisplatin therapy, I personally would consider a carboplatin-based regimen before considering anything else. If the patient's creatinine clearance is > 30 cc/min, I might give Carboplatin (AUC 6) for a T4 or N3 (Stage III) unresectable tumor.  Since p16+ tu...