What palliative, systemic treatment would you consider for a patient with an extensive Klatskin tumor with associated hyperbilirubinemia (bilirubin >20) not amenable to local intervention?

Specifically, would you consider incorporating immunotherapy in this setting?

Answer from: Medical Oncologist at Academic Institution

Localized Klatskin (hilar) cholangiocarcinomas defined as disease without nodal or metastatic spread and less than 3cm in size radially above the cystic duct are potential transplant candidates with the Mayo Clinic Protocol (Zamora-Valdes and Heimbach. PMID 29735023).For disease not meeting the abov...

Comments

Medical Oncologist at The Mark H Zangmeister Center
I have used 5 Fu or FOLFOX in the past but have ne...

Medical Oncologist at Columbia Basin Hem and Onc PLLC
My experience as well.

Answer from: Medical Oncologist at Academic Institution

Folfox.

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What palliative, systemic treatment would you consider for a patient with an extensive Klatskin tumor with associated hyperbilirubinemia (bilirubin >20) not amenable to local intervention?

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