What size cut-off do you suggest for the safe administration of SRS in the setting of brain metastases?
In RTOG 9508, 4 cm was the cut-off size for WBRT followed by SRS.
Answer from: Radiation Oncologist at Community Practice
The likelihood of radiation necrosis or acute treatment related imaging change does seem to increase with larger lesion size. I get worried once the target approaches 3 cm in diameter but have treated selected patients beyond that out to 4 cm using 15 - 16 Gy. We have an ongoing trial of...