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Topics:
Gastrointestinal Cancers • Medical Oncology • Liver and Pancreas Tumors • Neuroendocrine Tumors
What systemic therapy would you offer for a local, unresectable relapse of a mixed acinar neuroendocrine carcinoma of the pancreas?
What therapy would you offer if the patient had a baseline grade 2 neuropathy?
Answer from: Medical Oncologist at Community Practice
This is a very interesting question. I agree with the overall discussion with some points that need to be clear:
Did the pathology show mixed acinar and NEC with >30% of each component? or just acinar with NE features? I agree the data about MANEC is very limited and exclusively retrospective.
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Answer from: Medical Oncologist at Community Practice
MANEC's are a unique and extremely rare entity and hence, guidelines regarding management are limited. Their prognosis is poor due to aggressive tumor biology. Management can be extrapolated from high-grade neuroendocrine carcinoma of the GI tract and pancreatic adenocarcinoma in the mana...
Comments
Medical Oncologist at Cancer Centers of Southwest Oklahoma
Thank you very much for your detailed response. H...
Thank you very much for your detailed response. H...