What work-up should be considered in patients with significantly worsening A1c despite steady diet, lifestyle, and medication adherence?  

For patients with unexpected decompensation in glycemic control, I would start off by ensuring that their fingerstick or CGM glucose data correlates with their rising A1c. New medications (such as immunosuppressants or protease inhibitors) and anemia can falsely elevate A1c. I would then make sure ...