What workup do you do for patients who have PL-7 elevation when screening for myopathy?  

In the literature, the PL-7 antibody has been associated with the antisynthetase syndrome and aside from myositis, interstitial lung disease (ILD). Patients with PL-7 autoantibodies are at high risk of ILD. Referral to pulmonary should be considered. One would also consider assessing pulmonary funct...

I agree completely with Dr. @Taylor Harrison: PL-7+ patients may manifest any of the classic anti-synthethase syndrome (ARS) or dermatomyositis features, but several analyses have suggested that both PL-7+ and PL-12+ patients may have more significant ILD and more variable muscle involvement than Jo...