What would you recommend for a patient with a new or locally recurrent anal cancer s/p chemoRT for anal cancer 15 years ago?   

I would never irradiate a local recurrence of anal cancer for several reasons. The anal canal is a sensitive structure and the consequence of radiation injury is severe (ulceration, pain, bleeding). We could only give 39Gy in 26# BID or maybe 45Gy in 30#BID with two agent chemo. The cumulative dose ...