Would you dose escalate neoadjuvant radiotherapy for T3 and/or N+ rectal cancer in patients who are unwilling or unable to get chemotherapy?

If a patient with rectal cancer is not able and/or unwilling to receive concurrent radio-sensitizing chemotherapy with pre-operative intent radiotherapy, I would recommend the use of short-course radiotherapy with 25 Gy in 5 fractions.

Multiple trials, including TTROG 01.04 and Polish 1 Bujko et al.,...