When treating a high grade neuroendocrine tumor of the rectum with involved pelvic lymph nodes, do you use the same approach (dose, fractionation, concurrent chemotherapies) as you would for a small cell lung cancer?

Would you use platinum/etoposide concurrent with radiation or would you opt for platinum only during radiation?

Would you use BID fractionation and to what dose?

Answer from: Radiation Oncologist at Academic Institution

I have simply used standard radiation dose and technique with platinum/etopiside or CPT/cis. Twice a day fractionation could be very difficult to tolerate. The proctitis and small bowel toxicity would probably be too severe.

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Medical Oncologist at UH Seidman Cancer Center, Case Western Reserve University
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When treating a high grade neuroendocrine tumor of the rectum with involved pelvic lymph nodes, do you use the same approach (dose, fractionation, concurrent chemotherapies) as you would for a small cell lung cancer?

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