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Breast Cancer • Radiation Oncology
When treating an intact whole breast with hypofractionated radiation, how do you approach boost dosing in the case of a close margin?
In a setting of standard fractionation, we would sometimes consider going to 66Gy total dose to the boost cavity, so how would you "translate" this to the hypofractionated setting?
Answer from: Radiation Oncologist at Community Practice
In the Plenary session of the 2012 San Antonio Breast Cancer Symposium, Dr. John Yarnold reviewed all of the updates of the UK START and Royal Marsden HFRT trials and discussed the fact that 40 Gy in 15 fractions had become the standard for the UK's National Institute for Health Care and Excellence ...
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Answer from: Radiation Oncologist at Community Practice
Our schedule is 42.5 in 16 fractions followed by 2.5 x 4 to complete in 4 weeks and equivalent dose is similar to above schedule
Answer from: Radiation Oncologist at Academic Institution
According to the most recent 2018 ASTRO whole breast fractionation guidelines published in PRO, in the absence of strong risk factors for local recurrence such as those enumerated in KQ3B, 1000 cGy in 4 to 5 fractions is suggested as the standard tumor bed boost dose-fractionation, regardless of who...
Answer from: Radiation Oncologist at Academic Institution
I do 40 Gy in 16 fractions (2.5 Gy per fraction) to the breast and a boost of 13.75 Gy in 5 fractions (2.75 Gy per fraction) to the boost, which is almost the exact BED of 45 Gy in 25 fractions plus 16 Gy in 8 fractions. (This reflects a greater emphasis on the boost than the "50 Gy in 25 fractions ...