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When would you consider first line FOLFOXIRI + Bevacizumab for metastatic colon cancer?
How would the sidedness of the tumor, BRAF, RAS,HER2 or MSI status affect your decision?
Answer from: Medical Oncologist at Academic Institution
The phase III TRIBE study published in 2015 reported first line FOLFOXIRI with bevacizumab treatment had overall survival (OS) benefit compared with FOLFIRI/bevacizumab as first line treatment (29.8 months vs. 25.8 months, HR 0.80, p=0.03) (Cremolini et al., Lancet Oncol 2015). FOLFOXIRI/bevacizumab...
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Answer from: Medical Oncologist at Academic Institution
I consider modified-FOLFOXIRI based chemotherapy (with targeted agents) for most patients and use this frequently. Our colon cancer patients are much more robust than pancreatic patients who receive FOLFIRINOX, in general.
I definitely use this for BRAF mutated patients, those with symptoms o...
Answer from: Medical Oncologist at Community Practice
Great question! It's mportant to consider sidedness as well as the decision to not use anti-EGFR antibody. Here is a great review.