Would you consider use of belimumab in a patient with SLE with recurrent anterior uveitis who failed other treatment options?  

First, uveitis in SLE certainly happens, but it is rare, occurring in less than .5% of patients. So, we have scant evidence on how to treat it beyond case reports (to my knowledge). I have had SLE patients with uveitis (including anterior uveitis), but all responded fortunately to hydroxychloroquine...

I agree with Dr. @Thomas' thoughtful and thorough answer. I do not personally follow hydroxychloroquine levels but I also accept that this is an area for legitimate debate. I am always guided by matching "the punishment to the crime". Belimumab, rituximab, or anti-TNF are expensive punishments, so ...