Would you consider whole breast irradiation in a woman who develops a second primary breast cancer or recurrence after lumpectomy and partial breast balloon brachytherapy and declines mastectomy?   

In the case of a recurrence or second primary where the original irradiated soft tissue will be resected, I would first review the amount of dose delivered from the original APBI to the chest wall and skin.  I am mainly thinking of APBI delivered with a brachtherapy technique.  If the dose...

We have done it in few patients. To some extent, it is a function of the location of the new primary with respect to original disease and the effect of previous APBI on skin and cosmetic outcomes.