Would you ever consider oral doxycycline for treatment of either gram-negative or gram-positive uncomplicated bacteremia?  

I would not consider this a first or even second-line option due to the poor serum levels that are achieved. I supposed that this could be used for "mop up" therapy, but in such cases, it's almost as if you are using the doxy to treat yourself rather than the patient.

@Keith may have heard this story as his father, Dr. Donald Kaye, was an ID doc too. Maybe this story/legend helps answer this question, maybe not. Dr. Jay Sanford, creator of the Sanford Guide to Antimicrobial Therapy, was listening to a presentation on anti-virals from one of his ID fellows at NNMC...