Would you increase the hydroxychloroquine dose to more than 5 mg/kg/day in a compliant patient with active non-organ threatening lupus (skin+joints) if serum hydroxychloroquine is not at goal until you reach an acceptable concentration?  

Absolutely! Thanks for asking as this should be the trend in dosing.However, let's call this "non-life threatening lupus" instead of "non-organ threatening".Cutaneous lupus is one of the top reasons for the poor quality of life in lupus patients (Klein et al., PMID 21397983), so remission is our goa...

Yes, absolutely. I monitor levels of HCQ, but more so that I can have conversations about medication adherence, rather than concern for toxicity. I have been doing this for >3 years, and in that time, nearly 80% of my patients were SUB-therapeutic, and only 1 patient was above the recommended the...

Sharing clinical experiences, like that of Dr. @Cunningham is important. The reason why I seem crazy pushy about using HCQ drug levels is because: I started doing them on all patients after seeing Michelle Petri's presentation at SLEuro 2016; checking the HCQ level every visit caused adhere...