Would you offer adjuvant chemotherapy for MSI-H Stage II colon cancer with multiple high risk features?  

About 15-20% of colorectal cancers are found to be MSI-high. These tumors are generally associated with a superior prognosis to those who are MSI-stable. Thus, the question as to whether one should utilize adjuvant chemotherapy in the context of patients with stage II disease, a setting where adjuva...

I appreciate the cogent responses to my initial answer to the query above. Just to respond to a couple of the points raised: If there were a tumor deposit in the original tumor specimen, then this would no longer be a stage II tumor, and I would certainly agree with the need for adjuvant chemothera...