Would you offer immunotherapy for a patient with a history of kidney transplant on immunosuppression who has clear cell RCC in the native kidney?   

While data to address this question remains retrospective in nature, a number of small series suggest a very high solid organ rejection rate (37-41%) and worrisome morality rates in the 40+% range. Fully understanding the potential for survival benefit from ipi/nivo or pem/axi, I would be inclined t...