Would you offer whole breast RT in an elderly patient with early stage breast cancer with EIC?  

If the patient meets CALGB criteria and has negative margins, then EIC is not a contraindication to the omission of radiation. More generally, when deciding whom to treat among the universe of patients who meet CALGB criteria, factors that influence me are patient preferences and values (to what ex...

EIC in-and-of-itself would not drive me to offer RT given that CALGB 9343 likely included patients with this finding, among other high risk features. I would, however, consider the constellation of risk factors in trying to place this patient on the spectrum of CALGB9343 risk. For example, a patient...

I agree with the comments of my colleagues above, especially regarding shared decision making in discussion with the patient.  Not all elderly patients have indolent disease, so a thorough review of tumor markers and clinicopathologic risk features should be part of the decision proce...