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Would you omit pelvic XRT in a high risk prostate patient with negative nodal uptake on PSMA but has risk of nodal involvement >15% by nomogram?
Answer from: Radiation Oncologist at Community Practice
Based on POP-RT, if they are a high-risk group, I would add pelvic RT.
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Answer from: Radiation Oncologist at Community Practice
Agree with @Sushil Beriwal - this was precisely the question/population studied in POP-RT. Which nomogram to use is controversial, and POP-RT used the Roach formula with a >20% threshold. The question stem does not specify the risk model used, and the 15% threshold adds some controversy, in which...
Answer from: Radiation Oncologist at Academic Institution
No. In fact, the vast majority of the patients in the POP-RT study had negative PSMA scans!
Answer from: Radiation Oncologist at Community Practice
No way. I even treat the nodes in unfavorable intermediate with high Decipher and negative PET. The reason is OSPREY, which evaluated Pylarify preop in high risk. PyL (and likely Illucex) lack sensitivity for pelvic nodes, particularly less than 5 mm. Specificity was excellent as anticipated, but a ...