Would you recommend radiotherapy to upper-tract urothelial carcinoma in an inoperable patient?
Would treatment be palliative (i.e. for ureteral obstruction) or definitive? Is there a role for chemotherapy or hypofractionation/SBRT?
Answer from: Radiation Oncologist at Academic Institution
Unfortunately, there are no good data to guide a decision in this circumstance. Assuming that this is a patient with a small tumor localized to the upper tract with no evidence of nodal or distant disease, radiotherapy might be a reasonable option to either palliate symptoms due to obstruction or bl...
Answer from: Radiation Oncologist at Academic Institution
I am hardly an expert on the topic, but have performed SBRT in this scenario. I found this paper very helpful for treatment planning. Evans et al., PMID 29556581.
Comments
Radiation Oncologist at Advanced Oncology Associates The imaging shown also makes one cautious to call ...
Answer from: Radiation Oncologist at Community Practice
Yes, UTUC is dangerous especially high grade and older. Many aren't RUN candidates. Invasion is not easy to determine. There is data on SBRT along the upper tract. Topical mitomycin gel isnt the answer.Evans et al., PMID 29556581, Khriguian et al., PMID 34530170Also, if you treat a lot of primary re...