Please select the option that best describes you:
Would you recommend starting tolvaptan at 7.5 mg per day, which is half the typical starting dose, to reduce the risk of overcorrection in an inpatient with SIADH and a serum sodium level of 122 mEq/L?
Answer from: at Academic Institution
If it is for SIADH, I always start with 7.5 mg.
See this, my fellow and I put together years ago.
Dosing in SIADH: A Tale of Two Tolvaptans
If it is for CHF, I would start with 15 mg as those patients are so pre-renal, their distal delivery is so impaired, and tolvaptan is limited by that. I have...
Sign in or Register to read more
Answer from: at Academic Institution
Yes, tolvaptan at 7.5 mg per day can be effective in treating SIADH with a decreased rate of overcorrection.
Hanna et al., PMID 32734225