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Would you treat endometrioid adenocarcinoma arising from an endometriosis lesion in a patient with prior hyst/BSO like an ovarian or endometrial primary?
Example: in a patient with a non-resectable pelvic mass involving the vagina but without evidence of distant disease, would you favor pelvic RT (as one might do for locoregional non-resectable endometrial) or systemic chemotherapy (as one might do for ovarian)?
Answer from: at Community Practice
For a patient with prior hyst/BSO and now an endometriosis-associated endometrioid adenocarcinoma, I would start by getting next-generation sequencing and MSI/MMR testing of the tissue specimen that was used to make the diagnosis. This would allow for additional information and the potential use of ...
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Answer from: Radiation Oncologist at Academic Institution
I've seen a few cases where patients with a history of prior TAH for non-oncologic reasons 2+ years earlier developed endometrioid adenocarcinoma of the vaginal cuff, +/- nodal regional disease.
We treat definitively similar to how we would approach vaginal recurrence of endometrial cancer as...
Answer from: at Community Practice
In general, endometrioid adenocarcinomas arising in endometriosis after hysterectomy/BSO are classified as peritoneal carcinomas and are treated like ovarian cancer. Tumor molecular studies may add critical information in directing primary therapy.Background:Numerous epidemiologic studies have demon...