Would you use upfront immunotherapy in a patient with MSI high metastatic colon cancer in the setting of high volume disease?

Bulky hepatic metastasis

Answer from: Medical Oncologist at Academic Institution

These are challenging. I have used triplet in a couple of these who needed quick cytoreduction and for purposes on neoadjuvant for possible liver resection given the 30 percent primary refractory.

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Medical Oncologist at University of Vermont
I have not had this scenario come up in my practic...

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Would you use upfront immunotherapy in a patient with MSI high metastatic colon cancer in the setting of high volume disease?

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