Would you withhold adjuvant FOLFOX in stage III colon cancer if Signatera circulating tumor DNA testing is negative?
Answer from: Medical Oncologist at Academic Institution
No, not yet. GALAXY data (Kotani et al., PMID 36646802) suggest that adjuvant chemo does not benefit the ctDNA neg population, but the median follow-up is 16.74 months. If the longer-term data shows the same, you can make a case for de-escalation. For now, I would offer adjuvant FOLFOX to all resect...
Comments
Medical Oncologist at Memorial Sloan Kettering Cancer Center I don’t use ctDNA outside of a clinical tria...
Medical Oncologist at Joliet Oncology Hematology Associates I do not order ctDNA for these patients. In the co...
Answer from: Medical Oncologist at Academic Institution
I agree with Dr. @Chakrabarti completely that this is not the current standard of care, but is an area of active clinical investigation. In the United States, the CIRCULATE-US trial is looking at randomization to standard of care chemotherapy for low risk stage III colon cancer patients versus monit...
Answer from: Medical Oncologist at Community Practice
CtDNA use is picking up dramatically 'outside of clinical trials' and is reimbursed in most scenarios. The data while still maturing, is still strong in the different settings (prognostic for recurrence, and recently, conversion from positive to negative is also correlated with better outcomes).
In...
I don’t use ctDNA outside of a clinical tria...
I do not order ctDNA for these patients. In the co...