Register
Community
Overview
Experts
Editors
Fellows
Code of conduct
AI Guidelines for Physicians
Company
About Us
FAQs
Privacy Policy
Terms of Use
Careers
Programs
News
News Releases
Press Coverage
Publications
Blog
Contact Us
Sign in
Please select the option that best describes you:
Topics:
General Internal Medicine
•
Infectious Disease
•
Pulmonology
•
Pulmonary Infections
•
Non-Tubercular Mycobacteria
Are you using the microbial cell-free DNA “Karius” test to aid in the diagnosis of an atypical pulmonary infection such as PJP or NTM?
Answer from: at Academic Institution
No, not at this time. Intriguing, but not sure we know enough yet.
Sign in or Register to read more
Answer from: at Academic Institution
I ordered it once but it didn’t help in the diagnosis. The patient expired from multiple organ dysfunction syndrome (MODS) and sepsis. It is an expensive test, so I won’t be ordering it routinely.
Sign in or Register to read more
16531
16652
Related Questions
Would you start treatment for MAC in a patient with nodular bronchiectatic disease who has demonstrated radiographic progression but remains asymptomatic and smear-negative?
Do add a macrolide for immunomodulatory effect in patients with macrolide-resistant M. abscessus?
How would you treat an asymptomatic patient with a positive Blastomyces antibody, evidence of prior granulomatous lung disease on imaging, and who may require immunosuppression in the future?
What is the interpretation of two IGRAs with negative mitogen wells, in the absence of immunosuppression?
What further evaluation do you pursue for patients who present with vague symptoms such as subjective fevers or intermittent night sweats, who have no pulmonary symptoms but have a positive IGRA?
Is there any utility to trending Histoplasma serology titers to guide duration of therapy or treatment response for pulmonary histoplasmosis with negative urine antigen?
Have you used Karius to aid in the diagnosis of a non-resolving pneumonia, with negative bronchoscopy, biopsy, and other infectious work up in an immunocompetent patient?
What is the interpretation of an IGRA with positive TB wells and negative nil and negative mitogen wells?
Do you treat non-albicans strains of Candida on sputum culture or BAL in patients who are immunosuppressed?
What additional treatment strategies would you recommend for a patient with a Mycobacterium chelonae and Mycobacterium abscessus infection following bilateral prophylactic mastectomies and implant insertion, who has undergone multiple surgeries and an extended course of IV antibiotics selected based on sensitivities?