Based on the findings of the CALOR trial, among which group of patients with locoregional recurrence of hormone-receptor positive breast cancer would you treat with chemotherapy?   

Look at the circumstances associated with local recurrence, review original pathology, did relapse occur while on endocrine therapy or off it, how late,..etc. All these are important questions. Generally, the vast majority of ER-positive local recurrences do not need nor are they responsive to chem...