Nephrology

General Rheumatology

Questions discussed in this category

In the treatment of lupus nephritis, which patients may benefit from the use of rituximab or other B-cell depleting agents during induction?

This question is part of a collaboration with RheumMadness and is specifically in reference to: Obinutuzumab in Lupus Nephritis

2 Answers available

What are some important considerations for use of ACE inhibition in scleroderma renal crisis patients who require dialysis?

For example, is captopril dialyzable?

1 Answer available

How do you counsel patients who experience diarrhea from mycophenolate mofetil (Cellcept)?

Do you generally recommend anti-diarrheals, dietary modifications, or consider this an unacceptable side effect and move to other therapies?

2 Answers available

How would you approach management of a patient with ESRD on the transplant list who is found to have high titer APS labs (ACL, B2GP1, LAC)?

1 Answer available

Do you recommend sending an autoimmune work up for patients with recurrent nephrolithiasis and 24 hour urine chemistries consistent with distal renal tubular acidosis?

1 Answer available

Do you prefer celecoxib over a nonselective NSAID in patients with chronic kidney disease?

4 Answers available

Do you restrict topical diclofenac use in your patients with chronic kidney disease?

3 Answers available

What is your approach to a patient with IgG4RD with past pulmonary involvement (biopsy proven) managed with steroids alone, now with new hematuria/proteinuria, but stable renal function?

Would you obtain renal biopsy first or treat with additional immunosuppression for suspected renal involvement related to IgG4?

4 Answers available

Would you feel comfortable adding benlysta to patient already taking both mycophenolate and tacrolimus (and hydroxychloroquine) who still has some evidence of active lupus nephritis?

3 Answers available

What else do you consider in the differential diagnosis for pulmonary-renal syndromes if there is low clinical and serologic evidence of AAV, Goodpasture's or other rheumatologic disease (SLE, RA, APS, Scleroderma)?

2 Answers available

How do you manage patients with systemic sclerosis and chronic thrombotic microangiopathy on renal biopsy, but no other evidence of scleroderma renal crisis?

Patient with nephrotic range proteinuria, but there is no evidence of active TMA on renal biopsy.

1 Answer available

How would you manage tubulointerstitial nephritis and renal tubular acidosis (RTA) in a patient with Sjogren's who is pregnant?

2 Answers available

In which clinical scenarios is relying on the urine protein-to-creatinine ratio as a measure of proteinuria unreliable, and interpretations should be made looking at urine protein and urine creatinine separately?

1 Answer available

What is your treatment algorithm for management of retroperitoneal fibrosis that does not respond to high-dose glucocorticoids?

1 Answer available

Papers discussed in this category

Arthritis and rheumatism, 2012-04

Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study.

Ann Rheum Dis, 2013 Jun 05

Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids.

Annals of the rheumatic diseases, 2021 Oct 06

B-cell depletion with obinutuzumab for the treatment of proliferative lupus nephritis: a randomised, double-blind, placebo-controlled trial.

The New England journal of medicine, 2025 Feb 07

Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis.

Kidney international, 2009-12

A prospective study of protein excretion using short-interval timed urine collections in patients with lupus nephritis.

Clinical journal of the American Society of Nephrology : CJASN, 2010-07

Comparison of urinary albumin-creatinine ratio and albumin excretion rate in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study.

Journal of the American Society of Nephrology : JASN, 2010-08

Comparison of different measures of urinary protein excretion for prediction of renal events.

Am J Kidney Dis, 2016 Sep 16

Timed Urine Collections for Albumin and Protein: "The King Is Dead, Long Live the King!".

J Rheumatol, 2004 Aug

Urine protein-to-creatinine ratio is a reliable measure of proteinuria in lupus nephritis.

Nat Rev Nephrol, 2015 Nov 16

Renal involvement in primary Sjögren syndrome.

Annals of clinical and laboratory science, 2008

Nephrotic range proteinuria: rare manifestation of scleroderma renal crisis.

International journal of general medicine, 2019 Sep 02

Renal pathology and clinical associations in systemic sclerosis: a historical cohort study.

Ann Rheum Dis, 2020 Jan

The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease.

Arthritis and rheumatism, 2011-12

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus.

N Engl J Med,

Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis.

Lupus,

Hydroxychloroquine use predicts complete renal remission within 12 months among patients treated with mycophenolate mofetil therapy for membranous lupus nephritis.

Arthritis Rheumatol, 2017 Apr 07

Efficacy and Safety of Subcutaneous Belimumab in Systemic Lupus Erythematosus: A Fifty-Two-Week Randomized, Double-Blind, Placebo-Controlled Study.

Lancet (London, England), 2011 Feb 04

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial.

Therapeutic drug monitoring, 2022 Jun 01

Drug-Drug Interactions Between Mycophenolic Acid and Proton Pump Inhibitors: A Systematic Review and Meta-Analysis.

Nephrology

General Rheumatology

Questions discussed in this category

Papers discussed in this category

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