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Ophthalmology

Inflammatory eye disorders   

Questions discussed in this category

In a patient with isolated HLA B27+ anterior uveitis, how long would you continue immunosuppressive therapy?
The patient has no extraocular features of a spondyloarthropathy and is on methotrexate. No active eye disease for past 1 year.
2 Answers available
How would you approach the management of dry corneal melt in a patient requiring high dose systemic steroids and no apparent underlying systemic autoimmune disease?
1 Answer available
What would be your approach to a patient with Scleroderma/Myositis overlap syndrome (+anti-Ku) and active inflammatory eye disease despite high dose mycophenolate?
2 Answers available
How would you approach the management of HLA-B27-associated recurrent uveitis and inflammatory back pain with a recent history of melanoma?
4 Answers available
How would you approach management of incidentally identified unilateral retinal vasculitis with subsequent labs revealing +P-ANCA?
Patient is asymptomatic. Labs showed +P-ANCA 1:160. Negative MPO and PR3.
2 Answers available
How would you approach persistent episcleritis/uveitis due to PR3+ GPA, which needs low dose prednisone to control, despite induction with Rituximab?
Other manifestations improved (renal function has stabilized, fatigue, arthritis, and LCV have resolved). Ophthalmologist has controlled the uveitis u...
1 Answer available
How would you approach management of active bilateral pan uveitis in patients who have a history of prior infectious uveitis?
Patient with history of toxoplasma chorioretinitis, currently on oral and topical prednisone. 
2 Answers available
How do you approach the use of hydroxychloroquine in patients with a history of visual field defect from another cause such as macular degeneration or diabetic retinopathy?
3 Answers available
How would you manage scleritis perforans in a patient with seropositive rheumatoid arthritis/scleroderma overlap?
Patient has failed methotrexate and adalimumab. 
2 Answers available
What is your approach to immunosuppression in patients with recurrent peripheral ulcerative keratitis or marginal keratitis who have active disease despite steroid therapy and no current evidence of rheumatologic disease?
Is the approach different from uveitis immunosuppression?
4 Answers available
How do you evaluate patients who have panuveitis without any systemic symptoms?
1 Answer available
How do you decide on a steroid sparing agent for idiopathic orbital inflammation partially responsive to steroids?
1 Answer available
How would you treat corneal melt (in the absence of peripheral arthritis) in rheumatoid arthritis?
What immunosuppression and dosing do you typically use?
1 Answer available
What do you use to treat uveitis refractory to conventional synthetic DMARDs and TNF inhibitors?
Are IL-17 or IL-23 inhibitors helpful?
5 Answers available
How would you treat uveitis in a patient with a history of cutaneous T cell lymphoma?
Patient was previously well controlled on methotrexate, which was discontinued during cancer treatment.
1 Answer available
Do you extrapolate from uveitis treatment pathways when managing other inflammatory eye conditions such as atypical serpiginous choroiditis?
2 Answers available
Are there any situations in which you would consider starting steroid-sparing agents at the outset for patients with scleritis without any evidence of systemic rheumatic disease?
2 Answers available


Papers discussed in this category

Ophthalmology, 2015-05
Efficacy and safety of intravenous secukinumab in noninfectious uveitis requiring steroid-sparing immunosuppressive therapy.
Retina,
LONG-TERM OUTCOMES OF RITUXIMAB THERAPY IN PATIENTS WITH NONINFECTIOUS POSTERIOR UVEITIS REFRACTORY TO CONVENTIONAL IMMUNOSUPPRESSIVE THERAPY.
Ophthalmic Res, 2018 Apr 10
Cyclophosphamide or Rituximab Treatment of Scleritis and Uveitis for Patients with Granulomatosis with Polyangiitis.
Dev Ophthalmol, 2012 Apr 17
Rituximab for noninfectious uveitis.
Arthritis Rheumatol, 2019 Aug 12
Long-Term Outcome of Ustekinumab Therapy for Behçet's Disease.
American journal of ophthalmology, 2017-11
Primary (Month-6) Outcomes of the STOP-Uveitis Study: Evaluating the Safety, Tolerability, and Efficacy of Tocilizumab in Patients With Noninfectious Uveitis.
Int J Environ Res Public Health, 2021 Aug 01
Relationship of Hydroxychloroquine and Ophthalmic Complications in Patients with Type 2 Diabetes in Taiwan.
Annals of gastroenterology, 2023 May 25
Outcome of inflammatory bowel disease patients with prior malignancy.
Melanoma research, 2022 Aug 22
Melanoma risk during immunomodulating treatment.
Lancet (London, England), 2025 Jan 25
Stopping of adalimumab in juvenile idiopathic arthritis-associated uveitis (ADJUST): a multicentre, double-masked, randomised controlled trial.

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