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Radiation Oncology

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Questions discussed in this category

What is your preferred approach for managing oligoprogressive NSCLC during second-line or later systemic therapy if patient is otherwise responding well at other sites of disease?
2 Answers available
Is there ever a role for adjuvant chemotherapy and/or immunotherapy for early stage, N0 non-small cell lung cancer treated with SBRT alone?
5 Answers available
Do you incorporate immunotherapy in your multi-modality treatment after chemoradiation for patients with potentially resectable stage III superior sulcus NSCLC?
2 Answers available
Should IMPower010 results be extrapolated to superior sulcus tumors treated with chemoradiation and surgery?
1 Answer available
What radiation dose is appropriate for patients receiving induction chemoradiation prior to surgery for superior sulcus tumors?
3 Answers available
What is your approach to CNS surveillance in resected superior sulcus tumors given high rates of intracranial metastasis in this population?
1 Answer available
Do you ever withhold PCI for elderly patients with limited stage SCLC?
In elderly patients (>70-75) with a good performance status, does the risk of neurocognitive decline outweigh the benefit of PCI?
4 Answers available
Would you consider SBRT and adjuvant therapy for a 4cm, node-negative, non-oncogene driven, NSCLC not amenable to surgical resection?
1 Answer available
Are there clinical features that would lead you to consider combining SBRT + immunotherapy in a high risk early stage NSCLC?
1 Answer available
Is it reasonable to offer observation with MRI rather than immediate PCI for patients with limited stage SCLC?
7 Answers available
How do you incorporate PCI into your management of patients with extensive stage SCLC?
Given that prophylactic cranial irradiation (PCI) has been shown to decrease the incidence of symptomatic brain metastases in patients with extensive ...
4 Answers available
Do you have a maximum size cutoff for lung SBRT in central NSCLC?
E.g. for a 7cm central NSCLC, would you offer 8 fx SBRT or ChemoRT? Patient is not a surgical candidate.
6 Answers available
Do you hold immunotherapy when administering lung SBRT?
One example of this scenario would be a patient receiving consolidative durvalumab after chemoRT for stage III NSCLC who develops a new peripheral lun...
3 Answers available
Would you use a hippocampal sparing technique when treating with PCI for a limited stage small cell lung cancer?
2 Answers available


Papers discussed in this category

N Engl J Med, 2007 Aug 16
Prophylactic cranial irradiation in extensive small-cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2017-12
Prophylactic Cranial Irradiation (PCI) versus Active MRI Surveillance for Small Cell Lung Cancer: The Case for Equipoise.
Lancet Oncol., 2017-05-01
Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial.
Journal of the National Comprehensive Cancer Network : JNCCN, 2018-10
NCCN Guidelines Insights: Small Cell Lung Cancer, Version 2.2018.
JAMA Netw Open, 2019 Aug 2
Evolving Practice Patterns in the Use of Prophylactic Cranial Irradiation for Extensive-Stage Small Cell Lung Cancer.
JAMA Oncol, 2020 Jun 4
Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases: The FIRE-SCLC Cohort Study.
Pract Radiat Oncol, 2020 May - Jun
Radiation Therapy for Small Cell Lung Cancer: An ASTRO Clinical Practice Guideline.
J Thorac Oncol, 2021 Feb 02
Phase 3 Randomized Trial of Prophylactic Cranial Irradiation With or Without Hippocampus Avoidance in SCLC (NCT01780675).
J Clin Oncol, 2021 Jan 27
Radiation Therapy for Small-Cell Lung Cancer: ASCO Guideline Endorsement of an ASTRO Guideline.
Int J Radiat Oncol Biol Phys, 2020 Nov 18
Patterns of Disease Progression after Carboplatin/Etoposide + Atezolizumab in Extensive-Stage Small-Cell Lung Cancer (ES-SCLC).
J Clin Oncol, 2021 Aug 11
Randomized Phase III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small-Cell Lung Cancer (PREMER): A GICOR-GOECP-SEOR Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007-01-20
Induction chemoradiation and surgical resection for superior sulcus non-small-cell lung carcinomas: long-term results of Southwest Oncology Group Trial 9416 (Intergroup Trial 0160).
International journal of radiation oncology, biology, physics, 2012-10-01
Radiation therapy oncology group protocol 02-29: a phase II trial of neoadjuvant therapy with concurrent chemotherapy and full-dose radiation therapy followed by surgical resection and consolidative therapy for locally advanced non-small cell carcinoma of the lung.
J. Clin. Oncol., 2020 Feb 14
Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001.
Neuro Oncol,
Hippocampal avoidance whole-brain radiotherapy without memantine in preserving neurocognitive function for brain metastases: a phase II blinded randomized trial.
J Clin Oncol, 2021 Aug 11
Hippocampal Avoidance Prophylactic Cranial Irradiation: A New Standard of Care?
International journal of radiation oncology, biology, physics, 2011-09-01
Primary analysis of a phase II randomized trial Radiation Therapy Oncology Group (RTOG) 0212: impact of different total doses and schedules of prophylactic cranial irradiation on chronic neurotoxicity and quality of life for patients with limited-disease small-cell lung cancer.
The Lancet. Oncology, 2009-11
Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004-01-01
Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: results of a randomized phase III trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007-04-01
Regression after whole-brain radiation therapy for brain metastases correlates with survival and improved neurocognitive function.
Cancer, 2013-11-01
Effect of prophylactic cranial irradiation on survival in elderly patients with limited-stage small cell lung cancer.
Journal of geriatric oncology, 2015-03
Prophylactic cranial irradiation in elderly patients with small cell lung cancer: findings from a North Central Cancer Treatment Group pooled analysis.
International journal of radiation oncology, biology, physics, 2013-07-15
Decline in tested and self-reported cognitive functioning after prophylactic cranial irradiation for lung cancer: pooled secondary analysis of Radiation Therapy Oncology Group randomized trials 0212 and 0214.
JAMA, 2016-07-26
Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial.
Advances in radiation oncology, 2017
Factors influencing the utilization of prophylactic cranial irradiation in patients with limited-stage small cell lung cancer.
The New England journal of medicine, 1999-08-12
Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group.
The Lancet. Oncology, 2009-05
Standard-dose versus higher-dose prophylactic cranial irradiation (PCI) in patients with limited-stage small-cell lung cancer in complete remission after chemotherapy and thoracic radiotherapy (PCI 99-01, EORTC 22003-08004, RTOG 0212, and IFCT 99-01): a randomised clinical trial.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017-02
Prophylactic cranial irradiation after definitive chemoradiotherapy for limited-stage small cell lung cancer: Do all patients benefit?
Cancer, 2010 Aug 27
Utilization of prophylactic cranial irradiation in patients with limited stage small cell lung carcinoma.
J Clin Oncol, 2008 Dec 01
Prophylactic cranial irradiation in extensive disease small-cell lung cancer: short-term health-related quality of life and patient reported symptoms: results of an international Phase III randomized controlled trial by the EORTC Radiation Oncology and Lung Cancer Groups.
Int J Radiat Oncol Biol Phys,
Neurocognitive outcome in brain metastases patients treated with accelerated-fractionation vs. accelerated-hyperfractionated radiotherapy: an analysis from Radiation Therapy Oncology Group Study 91-04.
J Thorac Oncol, 2016 Oct 07
Prophylactic Cranial Irradiation for Patients with Surgically Resected Small Cell Lung Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-04-01
Role of Adjuvant Therapy in a Population-Based Cohort of Patients With Early-Stage Small-Cell Lung Cancer.
J. Natl. Cancer Inst.,
Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017-10
Patterns of failure in limited-stage small cell lung cancer: Implications of TNM stage for prophylactic cranial irradiation.
J Clin Oncol, 2023 Jan 31
Adjuvant Osimertinib for Resected EGFR-Mutated Stage IB-IIIA Non-Small-Cell Lung Cancer: Updated Results From the Phase III Randomized ADAURA Trial.
Lancet (London, England), 2023 Jul 18
Stereotactic ablative radiotherapy with or without immunotherapy for early-stage or isolated lung parenchymal recurrent node-negative non-small-cell lung cancer: an open-label, randomised, phase 2 trial.
Lancet (London, England), 2023 Jul 18
Safe and effective systemic therapy for early-stage non-small-cell lung cancer.
Radiation oncology (London, England), 2014-09-19
Stereotactic body radiation therapy (SBRT) for lung cancer patients previously treated with conventional radiotherapy: a review.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-06-01
Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors.
International journal of radiation oncology, biology, physics, 2018-08-01
Safety of Combined Immunotherapy and Thoracic Radiation Therapy: Analysis of 3 Single-Institutional Phase I/II Trials.
Int. J. Radiat. Oncol. Biol. Phys., 2016 Jul 15
A Prospective Clinical Trial Combining Radiation Therapy With Systemic Immunotherapy in Metastatic Melanoma.
Eur. Respir. J., 2018 Jan 04
Immunotherapy and pulmonary toxicities: can concomitant immune-checkpoint inhibitors with radiotherapy increase the risk of radiation pneumonitis?
Practical radiation oncology, 2018
Thoracic reirradiation with SBRT for residual/recurrent and new primary NSCLC within or immediately adjacent to a prior high-dose radiation field.
JAMA Oncol, 2019 Jul 11
Effect of Pembrolizumab After Stereotactic Body Radiotherapy vs Pembrolizumab Alone on Tumor Response in Patients With Advanced Non-Small Cell Lung Cancer: Results of the PEMBRO-RT Phase 2 Randomized Clinical Trial.
J Thorac Oncol, 2020 Sep 08
Phase 1/2 Trial of Pembrolizumab and Concurrent Chemoradiation Therapy for Limited-Stage SCLC.
N Engl J Med, 2017 Nov 16
Durvalumab after Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer.
JAMA, 2010-03-17
Stereotactic body radiation therapy for inoperable early stage lung cancer.
International journal of radiation oncology, biology, physics, 2015-06-01
Stereotactic Body Radiation Therapy for Non-Small Cell Lung Cancer Tumors Greater Than 5 cm: Safety and Efficacy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-05-20
Safety and Efficacy of a Five-Fraction Stereotactic Body Radiotherapy Schedule for Centrally Located Non-Small-Cell Lung Cancer: NRG Oncology/RTOG 0813 Trial.
Chest, 2003-11
Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non-small cell lung cancer.
Lancet, 2021 Sep 20
Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB-IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase 3 trial.
N Engl J Med, 2022 Apr 11
Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer.
Lancet (London, England), 2023 Dec 14
Standard-of-care systemic therapy with or without stereotactic body radiotherapy in patients with oligoprogressive breast cancer or non-small-cell lung cancer (Consolidative Use of Radiotherapy to Block [CURB] oligoprogression): an open-label, randomised, controlled, phase 2 study.

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