Do you ever consider alternate dosing strategies for hormone directed therapy in breast cancer patients who cannot tolerate these drugs despite other supportive care strategies?  

When a patient has not tolerated other supportive care strategies I often tell patients to stop for a week and see if the symptoms resolve. Then have them re-start very slowly - sometimes a 1/2 a pill every other day for a week then gradually up to a pill a day. There is no data that supports this a...