Do you use IL-1 inhibitors to prevent flares of gout or CPPD in patients who experience flares despite prophylaxis with colchicine, NSAIDs, and/or low-dose prednisone?  

I have used IL-1 inhibitors to control gout flares or gout flare recurrences in patients who have been refractory to standard gout flare or gout flare prophylaxis management. Likewise, on extremely rare occasions, I have used an IL-1 inhibitor for recurrent CPPD flares, though with mixed results.The...

I agree completely with Dr. @Baraf. While one shouldn't define practice solely by anecdote, I have had several unfortunately refractory crystal-arthritis patients who had marked response to IL-1 inhibitors, including a patient who had dramatic improvement within 24 hours of starting Anakinra for a h...