Do you use prophylactic defibrotide in pediatric patients undergoing BMT who are considered to be at high risk for development of VOD/SOS? What features make a patient high risk?   

Prophylactic defibrotide can indeed be used in pediatric patients undergoing bone marrow transplant (BMT) who are considered to be at a high risk for the development of veno-occlusive disease / sinusoidal obstruction syndrome (VOD/SOS). Studies, including those leading to defibrotide’s FDA ap...