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Gastrointestinal Cancers • Medical Oncology
Does the presence of signet ring or mucinous pathology alter your management of stage 2 colon cancer?
If you had a patient with otherwise average risk stage 2 colon cancer but had signet ring or mucinous components to their pathology, would this sway you towards recommending adjuvant chemotherapy?
Answer from: Medical Oncologist at Academic Institution
In general, both portend a worse prognosis. For stage II the benefit of chemotherapy is modest. I would strongly encourage considering the COBRA study if patient is stage IIA. https://clinicaltrials.gov/ct2/show/NCT04068103. Note that eligibility requires adenocarcinoma. I would do more frequent fol...
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