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Do you recommend concurrent chemotherapy with XRT for inoperable patients with stage I-II high-risk endometrial carcinoma?
Ie for patients who are inoperable due to comorbidities?
Answer from: Radiation Oncologist at Community Practice
For inoperable patients due to medical comorbidities, we have been reluctant to add chemotherapy because of the concern about side effects. For inoperable patients due to disease extent, we routinely add concurrent chemotherapy.https://www.ncbi.nlm.nih.gov/pubmed/25218303/
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Answer from: Radiation Oncologist at Academic Institution
We do add chemotherapy to definitive radiation therapy for the treatment of some patients with inoperable endometrial cancer despite the lack of level 1 evidence. One rationale is that chemotherapy will increase the regression of bulky disease within the cervix and uterine body which will improve br...