For patients with metastatic radioctive iodine refractory papillary thyroid carcinoma that is BRAF V600E mutant and rapidly progressive, would you consider dabrafenib/trametinib combo instead of lenvantinib or sorafenib first line?

Aggressive histology with tall cell variant papillary thyroid carcinoma that's progressed 2 months after RAI and while on TSH suppression, without transformation to anaplastic

Answer from: Medical Oncologist at Community Practice

This is an ongoing debate among endocrine and head and neck oncologists; we have phase III data of lenvantinib which is pretty strong, although with tolerance issues when used at full approved doses (24 mg/day, SELECT trial). On the other hand, there is only phase 2 data for BRAF positiv...

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For patients with metastatic radioctive iodine refractory papillary thyroid carcinoma that is BRAF V600E mutant and rapidly progressive, would you consider dabrafenib/trametinib combo instead of lenvantinib or sorafenib first line?

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