How do you approach colon cancer chemotherapy in a patient who has had documented coronary vasospasm with FOLFOX?

Is re-challenge with 5-FU safe? Do you consider Capecitabine?

Answer from: Medical Oncologist at Academic Institution

Although there are case reports of successful rechallenging with infusional 5-FU in the setting of calcium channel blocker treatment, I don't endorse this approach given the potential cardiac consequences. Capecitabine is not an appropriate alternative since it's just infusional 5-FU in a different ...

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Medical Oncologist at Mayo Clinic
I agree with the suggestion of FLOX. We have recen...

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How do you approach colon cancer chemotherapy in a patient who has had documented coronary vasospasm with FOLFOX?

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