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Internal Medicine • Rheumatology • Thrombocytopenia • Hematology • General Rheumatology • SLE
How do you approach evaluation for underlying rheumatologic disease in patients with chronic asymptomatic thrombocytopenia?
Thrombocytopenia is moderate (80-100,000 microL). No concomitant cytopenias present.
Answer from: at Academic Institution
APL testing as well as evaluation for SLE and Sjogrens with complement, urine, antibody testing, not just an ANA.
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Answer from: at Community Practice
Agree with Dr. @Cuoghi Edens. Of course, don't forget about the DDX for drug effect, pseudothrombocytopenia from clumping, infections (like hep C), liver dz, etc.But focusing on ruling out autoimmune disorders, adding a few Pearls:On PE look for painless oral ulcers on the palate, discoid lupus...