How do you approach transaminase elevations with use of allopurinol in gout?
Do you rechallenge with lower dose? What is your tolerance for mild persistent transaminitis?
Answer from: at Academic Institution
This is quite rare in my practice of the use of allopurinol. That may be because I discourage NSAID concomitant use in people with gout, given their concomitant hypertension, and NSAID-associated GI, renal, and liver toxicity.
1. If mild transaminitis happens, I would approach it as I do for any pa...