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Gastrointestinal Cancers • Medical Oncology
How do you chose the starting dose of capecitabine?
Do you start with 1250 mg/m2 BID and then dose reduce based on toxicities? Many studies across varied types of malignancies have shown good tolerability of Xeloda in non-US populations compared to US counterparts. Is there a genetic basis for the PK/PD difference?
Answer from: Medical Oncologist at Academic Institution
I never start or get to this dose. At best, US patients will tolerate 1,000 mg/m2 BID x14 days on/7 days off; younger patients typically have better tolerance.
There are clear ethinic differences, with Asian patients tolerating this drug better than non-Asians. Western Europeans appear to have bett...
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