How do you counsel patients with NF1 diagnosed with breast cancer regarding breast radiation?
Is breast conservation absolutely contraindicated? What is the true increase in risk of secondary malignancy? Is there a good reference?
Answer from: Radiation Oncologist at Community Practice
These patients tend to present with more aggressive breast cancers (higher grade and stage, and higher incidence of contralateral disease). They are also thought to be at increased risk of radiation-induced malignancy (including sarcomatous changes). In addition, screening and surveillance are chall...