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Gastrointestinal Cancers • Medical Oncology
How do you interpret discrepancies between MMR testing and MSI testing?
E.g. loss of PMS2 expression by IHC only but MSI stable by PCR.
Answer from: Medical Oncologist at Community Practice
Microsatellites are short repetitive sequences of 1 to 6 base pairs of DNA throughout the genome, mostly in noncoding regions. MSI tumors develop through a distinctive molecular pathway characterized by genetic instability in microsatellite DNA repeat sequences. MSI phenotype occurs due to germline ...
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