What is your preferred way of administering nivolumab/ipilimumab in GI cancers?

Nivo 3 + Ipi 1 Q2W x3 then Nivo alone? Or Nivo 3 Q2W & Ipi 1 Q6W until POD or toxicity? Or other?

Answer from: Medical Oncologist at Academic Institution

Thanks for the question.My preference would be Nivo 3 Q2W & ipi 1 Q6W due to the more favorable toxicity profile seen in the first-line CheckMate-142 trial (Lenz et al., PMID 34637336) compared to CheckMate-142 that was conducted in refractory setting (Overman et al., PMID 29355075). Thanks...

Comments

Medical Oncologist at Montefiore Einstein Cancer Center
If you drop ipi at some point due to G1-2 toxicity...

Medical Oncologist at University of Pittsburgh School of Medicine
Yes, there is anecdotal evidence addition of anti-...

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What is your preferred way of administering nivolumab/ipilimumab in GI cancers?

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