How do you manage GI side effects related to CFTR modulator therapy?  

We have found that for most patients liver enzymes abnormalities are small and transient; however, for about 1% of patients there are severe elevations and these patients are much more difficult to manage, even after withdrawal, and tough to re-challenge; it is also not patients with severe liver di...

Described GI side effects of CFTR modulator therapy ranged from non-specific abdominal discomfort to abnormal liver function test with the incidence reported between 2-25%. Only a small percentage of patients with GI side effects required discontinuation of treatment with the incidence range between...